Compact microscope-based optical tweezers system for molecular manipulation
نویسندگان
چکیده
منابع مشابه
A compact holographic optical tweezers instrument.
Holographic optical tweezers have found many applications including the construction of complex micron-scale 3D structures and the control of tools and probes for position, force, and viscosity measurement. We have developed a compact, stable, holographic optical tweezers instrument which can be easily transported and is compatible with a wide range of microscopy techniques, making it a valuabl...
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Forces hold everything together and determine its structure and dynamics. In particular, tiny forces of 1-100 piconewtons govern the structures and dynamics of biomacromolecules. These forces enable folding, assembly, conformational fluctuations, or directional movements of biomacromolecules over sub-nanometer to micron distances. Optical tweezers have become a revolutionary tool to probe the f...
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We have recently applied optical tweezers to study human erythrocyte deformation under various thermal-flow conditions, e.g. flow in an open space. Theoretically, Computation Fluid Dynamics (CFD) has been applied for simulating the complex flow-liposome interaction at different flow velocities. More importantly, both experimental and numerical studies have been carried out to determine the defo...
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In this article we use Lyapunov Second Theorem as well as LaSalle Theorem in order to determine the attraction region of an optical trap and to design an steering strategy to move a microscopic particle by means of optical tweezers. A variational approach based on Lagrangian formulation is used to obtain the equations of motion of a particle in the optical trap[1]. System is proved to be locall...
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We demonstrate the use of holographic optical tweezers for trapping and manipulating silicon nanomembranes. These macroscopic free-standing sheets of single-crystalline silicon are attractive for use in next-generation flexible electronics. We achieve three-dimensional control by attaching a functionalized silica bead to the silicon surface, enabling non-contact trapping and manipulation of pla...
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ژورنال
عنوان ژورنال: Review of Scientific Instruments
سال: 2003
ISSN: 0034-6748,1089-7623
DOI: 10.1063/1.1619545